NCT07447115
Exercise With and Without Cognitive Training
Not Yet Recruiting · Not Applicable · VA Office of Research and Development · registry updated 2026-03-03
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
This proposal aims to conduct a 10-week randomized controlled trial comparing walking and resistance training with and without computerized cognitive training in older Veterans with Multiple Sclerosis, followed by 12 months of fall tracking with sensors and fall calendars. The primary objectives of this proposed CDA2 are to provide critical preliminary data on 1) the feasibility of conducting a 10-week RCT, 2) preliminary treatment effects on gait, cognition, and falls, and 3) neuroinflammatory biomarkers. Dr. Katherine Hsieh will receive hands-on training in the design and conduct of clinical trials (Dr. Hackney), mechanisms underlying physical activity, cognitive rehabilitation, and falls (Drs. Twamley, Hackney, \& Kesar), fall detection technology (Prof. Sanford), and clinical problems faced by MS participants (Dr. Backus) to achieve her long-term career goal of becoming an independent falls prevention investigator.
Inclusion
- Diagnosis of Multiple Sclerosis
- Relapse free in the last 30 days
- Capable of standing unaided for at least 1 minute
- Expanded Disability Status Scale \<6.5
- Ability to speak and understand English
Exclusion
- Any neurological disorder other than MS
- Modified Telephone Interview for Cognitive Status \<20
- Current participation in an exercise or cognitive rehabilitation study